Invest Like the Best
Inside the AI lab
revolutionizing smell
| ft. Alex Wiltschko

aired [03.18.2025]


Host: Patrick O'Shaughnessy

Guest: Alex Wiltschko, Founder of Osmo

Key Insights

  • Osmo is revolutionizing scent by digitizing it with AI, chemistry, and neuroscience, enabling computers to "smell" and recreate odors.

  • The company’s tech, including a scent printer and olfactory intelligence, slashes custom fragrance creation from months to days.

  • Applications span fragrance design, counterfeit detection, and health diagnostics, with vast untapped potential in human wellness.

  • Osmo’s Generation platform democratizes scent creation, targeting businesses and creators seeking unique olfactory branding.

  • Challenges remain in miniaturizing tech for portability, but the vision is a handheld device that reads and recreates scents in real time.
1. Sniffing Out the Future: Osmo’s Mission to Digitize Smell

  • Osmo, founded by neuroscientist and AI expert Alex Wiltschko, aims to give computers a sense of smell, blending cutting-edge tech with human perception.

  • The company’s core goal is to analyze, understand, and recreate scents using a fusion of artificial intelligence, chemistry, and neuroscience.

  • Wiltschko’s drive stems from a childhood fascination with fragrance as a "magic potion" that alters perception, now channeled into a scientific and entrepreneurial quest.

  • Quote: "The mission of Osmo is to give computers a sense of smell, and all the applications that are born from that."
2. Decoding the Molecular Symphony: The Science Behind Smell

  • Smell, the oldest human sense, ties directly to memory and emotion via the brain’s hippocampus and amygdala, making it uniquely powerful.

  • Osmo employs gas chromatography and mass spectrometry (GCMS) to break scents into molecular components, separating and analyzing them like runners in a marathon.

  • A 300-dimensional "map of scent" powers their AI, decoding complex odors far beyond the simplicity of RGB color models.

  • Quote: "Smell is the most mysterious sense. It’s the first sense, evolutionarily, sipping little amounts of the chemical environment around us." — Alex Wiltschko.
3. Scent Printers and AI: Crafting Odors at Lightning Speed

  • Osmo’s "scent printer" mixes hundreds of primary odors—think CMYK for smells—to recreate any scent, from plums to custom fragrances.

  • Olfactory intelligence (OI) predicts how molecules smell and designs new ones, condensing a traditionally 12-18 month process into days.

  • The tech has already "teleported" a plum’s scent across the lab, a breakthrough moment proving digitization is possible.

  • Quote: "We've built a scent printer that can recreate any smell by mixing primary odors, and it’s allowing us to train the AI system." — Alex Wiltschko.
4. From Fragrance to Fraud Detection: Real-World Applications

  • Osmo’s Generation platform lets creators and businesses craft bespoke scents fast, targeting everyone from Instagram influencers to hotel chains like the Ritz-Carlton.

  • In security, Osmo partners with StockX, using shoe box-sized sniffers to detect counterfeit sneakers in 20 seconds by analyzing their unique odor fingerprints.

  • Health potential looms large: scent could diagnose illness early, as humans and dogs already sense sickness through subtle olfactory cues.

  • Quote: "The smell of the shoe is basically the fingerprint of everything that ever happened to make it, and we can tell real from fake." — Alex Wiltschko.
5. Scaling the Scent Mountain: Challenges and Ambitions

  • Miniaturization is the hurdle—current tech must shrink from lab-scale to pocket-sized, like AirPods, for mass adoption.

  • Osmo’s long-term vision is a dual-device system: one to read scents, another to recreate them, transforming how we interact with smell daily.

  • The strategy balances bold R&D with practical business steps, like Generation, to ensure survival and growth without betting the farm.

  • Quote: "The ultimate goal is something you can hold in your hand that can read the chemical slice of reality and recreate it." — Alex Wiltschko.
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